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  • Title: Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation.
    Author: Badarau E, Suzenet F, Bojarski AJ, Fînaru AL, Guillaumet G.
    Journal: Bioorg Med Chem Lett; 2009 Mar 15; 19(6):1600-3. PubMed ID: 19237285.
    Abstract:
    A new group of serotoninergic 5-HT(1A) or 5-HT(7) receptor ligands was identified. These compounds were designed and synthesized on a benzimidazolone scaffold and they enrich the well-known arylpiperazine class of 5-HT ligands. Diverse pharmacomodulations induced a shift in the affinity and selectivity profile with final identification of new potent hits.
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