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  • Title: [Role of specific iodothyronine-binding proteins in the process of nuclear-cytoplasmic thyroid hormone interrelationships in liver cells].
    Author: Turakulov IaKh, Mirakhmedov M, Iangunaev RA, Khamidkhodzhaeva D.
    Journal: Biull Eksp Biol Med; 1977 Jan; 83(1):17-9. PubMed ID: 192378.
    Abstract:
    A study was made of the role played by specific iodinethyrodine-binding proteins of rat hepatocytes in the process of nucleo-cytoplasmic interrelations of the thyroid hormones under normal conditions in thyroidectomy and in experimental thyrotoxicosis. The concentration of the hormone-binding sites in the cell depended on the thyroid hormone level outside the cell. An important role of the cytosol hormone-binding proteins in the accumulation and interacellular distribution of the thyroid cell hormones is emphasized. The absence of any participation of cytosol triiodine-thyronine binding proteins in the process ofpenetration of the hormone into the nucleus was revealed. Triiodine-thyronine level in the nuclei depended directly on the concentration of the recptor proteins in them and the degree of occupation of the acceptor sites in the receptors proper.
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