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  • Title: Cadmium excretion predicting hospital mortality and illness severity of critically ill medical patients.
    Author: Lin JL, Lin-Tan DT, Chu PH, Chen YC, Huang YL, Ho TC, Lin CY.
    Journal: Crit Care Med; 2009 Mar; 37(3):957-62. PubMed ID: 19237903.
    Abstract:
    OBJECTIVE: To determine the prognostic value of day 1 urine excretion of cadmium (1st DUE-Cd) for predicting outcomes in intensive care unit (ICU) patients. DESIGN: Prospective study. SETTING: ICUs in Chang Gung Memorial Hospital, Lin-Kou Medical Center, Taiwan, ROC. PATIENTS: Two hundred one ICU patients. INTERVENTIONS: Urine and blood samples were taken within 24 hours after admission. MEASUREMENTS AND MAIN RESULTS: Disease severity, hospital mortality, and number of organ failures were evaluated in each medical ICU patient. Stepwise multiple linear regression analysis indicated that a history of chronic hepatitis, serum albumin, and glutamic-pyruvic transaminase were significantly related to 1st DUE-Cd after adjusting for other related variables. Cox multivariate analysis revealed that serum blood urea nitrogen level and ICU 1st DUE-Cd were significantly related to hospital mortality after other risk factors and scoring systems were adjusted. Each 1-microg increase in ICU 1st DUE-Cd was associated with a 7% increase in hospital mortality rate. All patients with poisoning magnitude of cadmium excretion (>10 microg/day) died, except one and those with normal cadmium excretion survived. Chi-square values of the Hosmer-Lemeshow goodness-of-fit test were 6.936 (p = 0.544), and area under the receiver operating characteristic curve was 0.868 (95% confidence intervals: 0.82-0.92) for ICU 1st DUE-Cd. CONCLUSIONS: The ICU 1st DUE-Cd may predict hospital mortality in critically ill medical patients. Because of excess mortality and relatively small sample size, the predictive role of DUE-Cd needs further external validation.
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