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  • Title: Isolation of two new prenylflavonols from Epimedium brevicornum and their effects on cytokine production in vitro.
    Author: Luo GJ, Ci XX, Ren R, Wu ZY, Li HM, Li HZ, Li RT, Deng XM.
    Journal: Planta Med; 2009 Jun; 75(8):843-7. PubMed ID: 19242901.
    Abstract:
    In an attempt to search for bioactive natural products, two new prenylflavonols, 2''-hydroxy-3''-en-anhydroicaritin (1) and 2''-hydroxy-beta-anhydroicaritin (2), were isolated from the Chinese medicinal herb Epimedium brevicornum. Their structures were determined by 1D and 2D NMR spectroscopic analysis. The effects of compounds 1 and 2 on cytokine production in vitro were investigated. Compound 1 could significantly downregulate tumor necrosis factor-alpha (TNF-alpha) production and increase interleukin-10 (IL-10) production. These results suggested that compound 1 may have anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated mouse macrophages. In addition, the biogenetic relationships among compounds 1 and 2 are discussed.
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