These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A nutrigenomic inflammation-related PBMC-based approach to predict the weight-loss regain in obese subjects.
    Author: Goyenechea E, Parra D, Crujeiras AB, Abete I, Martínez JA.
    Journal: Ann Nutr Metab; 2009; 54(1):43-51. PubMed ID: 19246894.
    Abstract:
    BACKGROUND: Long-term maintenance of a dietary-induced weight loss continues to be a major health problem and warrants research on innovative approaches to understand weight stability. We investigated the role of the proinflammatory status on weight changes in obese subjects receiving a low-calorie diet (LCD) and during the subsequent 6-month weight maintenance period. METHODS: Eighty-four subjects (age: 34.2 +/- 0.53 years; body mass index, BMI: 30.4 +/- 1.8 kg/m(2)) followed an 8-week LCD intervention and were contacted again 6 months later. Body composition, circulating proinflammatory markers [tumor necrosis factor (TNF)alpha, interleukin-6, C-reactive protein and leptin] and mRNA levels of inflammation-related genes [TNFalpha and nuclear factor (NF) kappaB transcription subunits] in peripheral blood mononuclear cells (PBMC) were evaluated. RESULTS: The 6-month weight regain was predicted by high concentrations of TNFalpha at LCD completion (OR = 4.21, p = 0.036) along with the baseline amount of fat mass (OR = 7.23, p = 0.029). In addition, baseline leptin concentrations (p = 0.028) as well as mRNA levels of TNFalpha and NFkappaB subunits were higher at the end of the dietary intervention (p < 0.05) in PBMC of subjects who regained >or=10% of the dietary-induced weight loss. CONCLUSIONS: These findings demonstrate a role for the proinflammatory state and body adiposity in the prediction of weight-loss regain. This relationship could contribute to the design of more personalized nutritional treatments in obese patients and favor the weight maintenance process.
    [Abstract] [Full Text] [Related] [New Search]