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  • Title: Study of normal breast tissue by in vivo volume localized proton MR spectroscopy: variation of water-fat ratio in relation to the heterogeneity of the breast and the menstrual cycle.
    Author: Sharma U, Kumar M, Sah RG, Jagannathan NR.
    Journal: Magn Reson Imaging; 2009 Jul; 27(6):785-91. PubMed ID: 19249170.
    Abstract:
    PURPOSE: To investigate the alterations in water-fat (W-F) ratio of the normal breast tissue of female volunteers as a function of the histological phases of the menstrual cycle. METHODS: Image-guided volume localized in vivo proton ((1)H) magnetic resonance spectroscopy (MRS) at 1.5 T was carried out in the para-areolar region and the upper and lower quadrants of the normal breast tissue of volunteers (n=29; mean age 33.7+/-6 years) during five histological phases of the menstrual cycle. RESULTS: A W-F value of 0.90+/-0.41 was observed for the para-areolar region during the proliferative phase, which reduced to 0.46+/-0.21 and 0.45+/-0.25 during follicular and luteal phases, respectively. The value increased to 0.76+/-0.61 during secretory and to 0.87+/-0.37 during menstrual phases. No significant difference was observed in the W-F value for the upper and the lower quadrants of the breast during various phases of the menstrual cycle. However, the W-F ratio of the para-areolar region was significantly higher compared to the upper and the lower quadrants during all phases. This reflects the dependence of W-F value on the amount of glandular and adipose tissues and the heterogeneous nature of the breast. CONCLUSIONS: Our results indicate that changes in the normal breast tissue characteristics occur due to physiological factors like menstrual cycle that strongly influences the W-F value especially the para-areolar region in a cyclic manner. Thus any assessment of breast pathology using W-F values should be carried out carefully taking into consideration the location of the tumor within the breast as well as the time of menstruation.
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