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  • Title: Heat shock protein 27 in neuronal survival and neurite outgrowth.
    Author: Read DE, Gorman AM.
    Journal: Biochem Biophys Res Commun; 2009 Apr 24; 382(1):6-8. PubMed ID: 19249290.
    Abstract:
    The small heat shock protein 27 (Hsp27) is well documented to promote neuronal survival in neurodegenerative diseases and following nerve injury. It can directly inhibit apoptotic pathways, and as a chaperone it can ameliorate the toxic effects of misfolded proteins. More recently, Hsp27 has been implicated to also play a role in neurite outgrowth. Thus, Hsp27 is situated at the intersection of neuronal survival and differentiation and, as such, it has dual potential as a key therapeutic target for neuroregeneration.
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