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  • Title: Design, synthesis, and anti-HCV activity of thiourea compounds.
    Author: Kang IJ, Wang LW, Lee CC, Lee YC, Chao YS, Hsu TA, Chern JH.
    Journal: Bioorg Med Chem Lett; 2009 Apr 01; 19(7):1950-5. PubMed ID: 19251415.
    Abstract:
    A series of thiourea derivatives were synthesized and their antiviral activity was evaluated in a cell-based HCV subgenomic replicon assay. SAR studies revealed that the chain length and the position of the alkyl linker largely influenced the in vitro anti-HCV activity of this class of potent antiviral agents. Among this series of compounds synthesized, the thiourea derivative with a six-carbon alkyl linker at the meta-position of the central phenyl ring (10) was identified as the most potent anti-HCV inhibitor (EC(50) = 0.047 microM) with a selectivity index of 596.
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