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  • Title: Translating pathology in multiple sclerosis: the combination of postmortem imaging, histopathology and clinical findings.
    Author: Seewann A, Kooi EJ, Roosendaal SD, Barkhof F, van der Valk P, Geurts JJ.
    Journal: Acta Neurol Scand; 2009 Jun; 119(6):349-55. PubMed ID: 19254283.
    Abstract:
    BACKGROUND: Studies combining postmortem magnetic resonance imaging (MRI) and histopathology have provided important insights into the abnormalities reflected by MRI. MATERIALS AND METHODS: A short overview of these studies applied to multiple sclerosis (MS) is provided in this review, and the Amsterdam postmortem imaging protocol is specifically highlighted. CONCLUSION: Postmortem MRI and histopathology correlation studies have enabled a direct translation of basic pathology in MS to the clinical setting, and have simultaneously served as a biological validation of new MRI techniques.
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