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Title: Iron sensing as a partnership: HFE and transferrin receptor 2. Author: Fleming RE. Journal: Cell Metab; 2009 Mar; 9(3):211-2. PubMed ID: 19254564. Abstract: The mechanism by which HFE participates in the regulation of iron homeostasis has remained enigmatic. Gao et al. (2009) make the key discovery that the regulation of hepcidin in response to holotransferrin requires the interaction between HFE and transferrin receptor 2 (TfR2).[Abstract] [Full Text] [Related] [New Search]