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  • Title: [Optimization of chemotherapy regimens in children with primary pulmonary tuberculosis].
    Author: Ovchinnikova IuE, Starshinova AA, Dovgaliuk IF.
    Journal: Probl Tuberk Bolezn Legk; 2009; (1):36-40. PubMed ID: 19256011.
    Abstract:
    The efficiency of treatment was analyzed in 142 children aged 3-14 years who had local forms of primary pulmonary tuberculosis. Therapy was performed according to regimens 3 and 1, by using individual dosage regimens depending on the extent and severity of a specific process, the presence of complications, and age-related features. In minor tuberculosis, solitary calcifications being detected without signs of the activity of tuberculous infection, the basic course of therapy was 6-8 months; it was performed using 2 drugs in individual cases. In disseminated and complicated processes, eliminated intoxication and visible X-ray inflammatory changes were observed in 58.8-61.7% of children by months 3-4 of treatment, which required a longer intensive phase, by administering 3 drugs in the continuation phase till 6-9 months.
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