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  • Title: [Study on activity and mechanism of Sini Decoction anti-mitochondrial oxidation injury caused by myocardial ischemia/reperfusion].
    Author: Zhao DY, Zhao MQ, Wu WK.
    Journal: Zhong Yao Cai; 2008 Nov; 31(11):1681-5. PubMed ID: 19260280.
    Abstract:
    OBJECTIVE: To study the activity and mechanism of Sini Decoction (SND) Anti-mitochondrial Oxidation Injury caused by Myocardial Ischemia/Reperfusion. METHODS: Kun ming mice were randomly divided into three groups: Control group, Ischemia/Reperfusion (I/R) group and SND-treated group. At the end of experiment,hearts of mice were taken out for further detection. Activity of myocardium and mitochondrial SOD, content of myocardium and mitochondrial MDA, swelling of mitochondria, Lactic Acid content of myocardium and MnSODmRNA expression were observed. RESULTS: SND could increase the activity of myocardium and mitochondrial SOD (P<0.01), decrease the content of myocardium and mitochondrial MDA (P<0.01), decrease the Lactic Acid content of myocardium, lighted the swelling of mitochondria (P<0.01) and change the expression of MnSODmRNA (P<0.01). CONCLUSION: Sini decoction can anti-mitochondrial oxidation injury caused by Myocardial Ischemia/Reperfusion, its mechanism may be relate to increasing the MnSODmRNA expression.
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