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  • Title: Idiopathic hypogonadotropic hypogonadism in selective human gonadotropin deficiency in adult man: a case report.
    Author: Volpi R, Ugolotti MC, Carbucicchio A, Delsignore R.
    Journal: Acta Biomed; 2008 Dec; 79(3):251-4. PubMed ID: 19260388.
    Abstract:
    We report a rare case of idiopathic hypogonadotropic hypogonadism in an adult male (31-year-old), who underwent an endocrinological examination because of erectile dysfunction and suspected infertility. Laboratory data showed isolated gonadotropin deficiency. Magnetic resonance imaging (MRI) of the hypothalamic-pituitary unit showed no tumoral expansions. The patient was tested with gonadotropin releasing hormone (Gn-RH) (100 microg as an i.v. bolus injection). No significant LH and FSH responses were observed. Idiopathic hypogonadotropic hypogonadism is usually caused by hypothalamic lesions, however, since Gn-RH was unable to stimulate LH and FSH secretions, we supposed that our patient was affected by defective gonadotropin secretion at pituitary level.
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