These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Coexpression of cyclooxygenase-2 and vascular endothelial growth factor in gastrointestinal stromal tumor: possible relations to pathological parameters and clinical behavior.
    Author: Miao R, Liu N, Wang Y, Li L, Yu X, Jiang Y, Li J.
    Journal: Hepatogastroenterology; 2008; 55(88):2012-5. PubMed ID: 19260469.
    Abstract:
    BACKGROUND/AIMS: Currently, the clinicopathological significance of coexpression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in gastrointestinal stromal tumors (GISTs) has not been fully described. METHODOLOGY: The present study was designed to investigate the co-expression of the two markers and its significance in 54 patients with GIST by means of immunohistochemistry. RESULTS: We demonstrated that the expressions of COX-2 and VEGF were significantly higher in malignant GIST than those in benign and potentially malignant GIST (p<0.01). A significant correlation was found between COX-2 and VEGF expression. In addition, the expressions of COX-2 and VEGF were significantly correlated with pattern of tumor growth, the size of tumors, and the central necrosis of tumors (p<0.01 or p<0.05). Five-year survival rates were much lower in patterns with high expression of COX-2 and VEGF than those with low expression (p<0.01). Overexpression of COX-2 and VEGF in GIST may enhance the possibility of growth, invasion, and metastasis. CONCLUSIONS: The levels of COX-2 and VEGF expression can be used as objective parameters in distinguishing benign from malignant, judging the malignant degree, and predicting the prognosis of patients with GIST.
    [Abstract] [Full Text] [Related] [New Search]