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  • Title: Unraveling inner ear induction by gene manipulation using Pax2-Cre BAC transgenic mice.
    Author: Ohyama T.
    Journal: Brain Res; 2009 Jun 24; 1277():84-9. PubMed ID: 19265685.
    Abstract:
    One of the biggest drawbacks of conventional mouse knockout techniques in the study of the inner ear is that loss of a gene of interest may cause embryonic lethality before the inner ear develops. Thus, there is a need for an inner ear-specific gene manipulation system for loss- and gain-of-function analysis in the mouse inner ear. We generated a Pax2-Cre BAC transgenic line in which Cre recombinase expression recapitulates Pax2 expression in the presumptive otic ectoderm. Here, we present a brief summary of a recent model of inner ear induction suggested by the results of inner ear-specific gene modification using Pax2-Cre mice.
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