These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis of glucoconjugates of oleanolic acid as inhibitors of glycogen phosphorylase.
    Author: Cheng K, Liu J, Liu X, Li H, Sun H, Xie J.
    Journal: Carbohydr Res; 2009 May 12; 344(7):841-50. PubMed ID: 19269628.
    Abstract:
    Synthesis and biological evaluation of glucoconjugates of oleanolic acid, linked by either a triazole moiety or an ester function, as novel inhibitors of glycogen phosphorylase have been described. Several triterpene-glycoside conjugates exhibited moderate-to-good inhibitory activity against rabbit muscle GPa. Compound 12 showed the best inhibition with an IC(50) value of 1.14 microM. Structure-activity relationship (SAR) analysis of these inhibitors is also discussed. Possible binding modes of compound 12 were explored by molecular docking simulations.
    [Abstract] [Full Text] [Related] [New Search]