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  • Title: Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine.
    Author: Abd El-Sattar Fahmy S, Christensen JM, Ayres JW.
    Journal: Drug Dev Ind Pharm; 2009 Aug; 35(8):1009-21. PubMed ID: 19274589.
    Abstract:
    Nifedipine release from coated commercially available immediate release soft elastic gelatin capsules was investigated. Capsules were spray coated using two different polymeric combinations, ethylcellulose and hydroxypropylmethylcellulose or pectin, at different coating loads. In vitro drug release studies were conducted in three different dissolution media: with gastric pretreatment, without gastric pretreatment, and in water to investigate the pH effect on nifedipine release. Convolution of in vitro dissolution data for selected formulations and commercially available sustained release nifedipine formulations showed that the tested formulations provided release profiles of nifedipine that are very promising in terms of desirable sustained release formulations.
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