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  • Title: Estimating the lipophilicity of a number of 2-amino-1-cyclohexanol derivatives exhibiting anticonvulsant activity.
    Author: Pekala E, Marona H.
    Journal: Biomed Chromatogr; 2009 May; 23(5):543-50. PubMed ID: 19277952.
    Abstract:
    The lipophilicity of a number of N-acyl derivatives of trans- or cis-: racemic, (1R,2R)- or (1S,2S)-aminocyclohexanol (1-13) exhibiting anticonvulsant activity was investigated. Their lipophilicity (R(m0)) was determined using reversed-phase thin-layer chromatography (RP-TLC) with mixtures of methanol and water as mobile phases. The partition coefficients of compounds 1-13 (log P) were also calculated using two computer programs (Pallas and Chem DU) and compared with R(m0).
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