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  • Title: Beta-glycosidation of sterically hindered alcohols.
    Author: Szpilman AM, Carreira EM.
    Journal: Org Lett; 2009 Mar 19; 11(6):1305-7. PubMed ID: 19281135.
    Abstract:
    The 2-chloro-2-methylpropanoic ester serves as a steering group in the Schmidt glycosidation reaction. Rapid and efficient glycosidation of a range of sterically hindered alcohols takes place under mild, acidic conditions to afford the glycoside products in high yield and beta-selectivity and without formation of orthoester side products. The 2-chloro-2-methylpropanoic ester is readily cleaved under mild, basic conditions.
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