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  • Title: New atpenins, NBRI23477 A and B, inhibit the growth of human prostate cancer cells.
    Author: Kawada M, Momose I, Someno T, Tsujiuchi G, Ikeda D.
    Journal: J Antibiot (Tokyo); 2009 May; 62(5):243-6. PubMed ID: 19282876.
    Abstract:
    The growth and metastasis of prostate cancer are regulated by prostate stroma through the tumor-stromal cell interactions. Small molecules that modulate the tumor-stromal cell interactions will be new anticancer drugs. In the course of our screening of the modulators, we isolated two new atpenins, NBRI23477 A (4) and B (5), from the fermentation broth of Penicillium atramentosum PF1420. Compounds 4 and 5 as well as atpenin A4 (1), A5 (2) and B (3) inhibited the growth of human prostate cancer DU-145 cells in the coculture with human prostate stromal cells more strongly than that of DU-145 cells alone.
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