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  • Title: Changes in cyclic GMP levels during forelimb regeneration in adult Notophthalmus viridescens.
    Author: Liversage RA, Rathbone MP, McLaughlin HM.
    Journal: J Exp Zool; 1977 Apr; 200(1):169-75. PubMed ID: 192831.
    Abstract:
    Cyclic 3', 5'-guanosine monophosphate (cGMP) was measured at eight stages of forelimb regeneration in adult newts and compared with the cGMP levels of non-regenerating control limbs. There was a significant increase in cGMP content during dedifferentiation followed by a sharp decrease to minimal levels at the cone stage. A second smaller increase in cGMP occurred between the cone stage and mid-differentiation, followed by a decrease to relatively constant levels approaching control values as differentiation progressed. The changes in cGMP during dedifferentiation and during the period of highest cell proliferation indicate that cGMP may play a role in these processes. The smaller increases in cGMP levels during differentiation may reflect a reduced rate of cell division in the differentiating tissues.
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