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  • Title: An enantioselective organocatalytic approach to both enantiomers of lasubine II.
    Author: Verkade JM, van der Pijl F, Willems MM, Quaedflieg PJ, van Delft FL, Rutjes FP.
    Journal: J Org Chem; 2009 Apr 17; 74(8):3207-10. PubMed ID: 19284717.
    Abstract:
    A concise stereoselective route providing access to both enantiomers of the bioactive quinolizidine alkaloid lasubine II has been developed. The enantioselectivity was introduced by taking advantage of a proline-catalyzed asymmetric Mannich reaction. Next, the bicyclic system was constructed via a diastereoselective Mannich cyclization and subsequent ring-closing metathesis as the key steps.
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