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  • Title: Rapid multi-residue analysis of antibiotics in muscle by liquid chromatography-tandem mass spectrometry.
    Author: Granelli K, Elgerud C, Lundström A, Ohlsson A, Sjöberg P.
    Journal: Anal Chim Acta; 2009 Apr 01; 637(1-2):87-91. PubMed ID: 19286016.
    Abstract:
    A way of carrying out simple and rapid multi-residue analysis of antibiotics in porcine and bovine muscle by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is described. The method has previously been published as a screening method, but the scope has now been extended to quantification and confirmation. Nineteen compounds from five different classes of antibiotics, i.e. tetracyclines, sulfonamides, quinolones, (-lactams and macrolides, are included in the method. The samples are extracted by a single extraction using 70% methanol, diluted with water and injected in the LC-MS/MS. The run time is 7min per injection. About 60 samples can be analysed in 24h. By using this method the need for a separate screening step prior to confirmation is eliminated and consequently the total time from sampling to a confirmed result will be considerably reduced. Validation was performed according to Commission Decision 2002/657/EC.
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