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  • Title: Hypocarbia as a pathogenic factor in pontosubicular necrosis.
    Author: Hashimoto K, Takeuchi Y, Takashima S.
    Journal: Brain Dev; 1991 May; 13(3):155-7. PubMed ID: 1928607.
    Abstract:
    In neonates pontosubicular necrosis (PSN) is one of the patterns of acute brain injury, the sites of maximum damage being the basis pontis and the subiculum of the hippocampus. A retrospective clinical and pathological study was performed on 16 preterm and 2 term neonates with PSN and compared with 16 age-matched controls. The results indicated that hypocarbia of less than 20 mmHg was one of the important factors in the pathogenesis of PSN.
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