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  • Title: Chronic meningitis by histoplasmosis: report of a child with acute myeloid leukemia.
    Author: Pereira GH, Pádua SS, Park MV, Muller RP, Passos RM, Menezes Y.
    Journal: Braz J Infect Dis; 2008 Dec; 12(6):555-7. PubMed ID: 19287853.
    Abstract:
    Meningitis is a common evolution in progressive disseminated histoplasmosis in children, and is asymptomatic in many cases. In leukemia, the impaired of the T cells function can predispose to the disseminated form. The attributed mortality rate in this case is 20%-40% and the relapse rate is as high as 50%; therefore, prolonged treatment may be emphasized. We have described a child with acute myeloid leukemia (AML), that developed skin lesions and asymptomatic chronic meningitis, with a good evolution after prolonged treatment with amphotericin B deoxycholate followed by fluconazole.
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