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  • Title: Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.
    Author: Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R.
    Journal: Bioorg Med Chem Lett; 2009 Apr 15; 19(8):2154-7. PubMed ID: 19289282.
    Abstract:
    Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.
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