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  • Title: Recent topics related to human herpesvirus 6 cell tropism.
    Author: Mori Y.
    Journal: Cell Microbiol; 2009 Jul; 11(7):1001-6. PubMed ID: 19290911.
    Abstract:
    Human herpesvirus 6 (HHV-6) is a T lymphotropic herpes virus that is categorized into two variants, A (HHV-6A) and B (HHV-6B), on the basis of distinct genetic, immunological and biological characteristics. HHV-6 uses human CD46 as a cellular receptor. Without viral replication, HHV-6A induces cell-cell fusion between cells expressing human CD46. Some HHV-6B strains can also induce CD46-mediated cell-cell fusion. A multiple glycoprotein complex composed of glycoprotein (g) H-gL complexed with gQ1 and gQ2 has been identified, and found to be a viral ligand for the human CD46 receptor. Moreover, a novel complex consisting of gH/gL/gO, which does not associate with CD46, has also been identified. The evidence suggests that an additional receptor for HHV-6B or both variants may play a role in determining the cell tropism of this virus. Finally, cholesterol in the HHV-6 envelope and plasma membrane of the host cells plays an important role in HHV-6 entry, although how this function relates to cell-envelope fusion remains to be elucidated.
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