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  • Title: Nocardia asteroides pneumonia complicating low dose methotrexate treatment of refractory rheumatoid arthritis.
    Author: Cornelissen JJ, Bakker LJ, Van der Veen MJ, Rozenberg-Arska M, Bijlsma JW.
    Journal: Ann Rheum Dis; 1991 Sep; 50(9):642-4. PubMed ID: 1929588.
    Abstract:
    Low dose methotrexate is used increasingly often in the treatment of rheumatoid arthritis. Severe complications due to toxicity of the lung or bone marrow occur infrequently. This report describes a 71 year old woman with longstanding rheumatoid arthritis who developed pleuritis, a pulmonary infiltrate, and pancytopenia during treatment with low dose methotrexate. Fatal respiratory insufficiency followed, and cultures from the lung after death showed Nocardia asteroides.
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