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  • Title: Synthesis of 3-aryl-8-oxo-5,6,7,8-tetrahydroindolizines via a palladium-catalyzed arylation and heteroarylation.
    Author: Gracia S, Cazorla C, Métay E, Pellet-Rostaing S, Lemaire M.
    Journal: J Org Chem; 2009 Apr 17; 74(8):3160-3. PubMed ID: 19296664.
    Abstract:
    A selective palladium-catalyzed arylation and heteroarylation of 8-oxo-5,6,7,8-tetrahydroindolizines has been developed. Mechanistic studies assume an electrophilic substitution pathway for this transformation. This method provides an efficient one-step synthesis of 3-aryl-8-oxo-5,6,7,8-tetrahydroindolizines.
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