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  • Title: Cardio-renal protection with aliskiren, a direct renin inhibitor, in the ASPIRE HIGHER program.
    Author: Lee HY, Oh BH.
    Journal: Expert Rev Cardiovasc Ther; 2009 Mar; 7(3):251-7. PubMed ID: 19296761.
    Abstract:
    Aliskiren is the first in a new class of orally effective direct renin inhibitors. Initial results of clinical efficacy studies have demonstrated at least equivalent or superior blood pressure-lowering efficacy when compared with existing drugs, and a favorable side-effect profile either as monotherapy or as a component of combination therapy. This report aims to introduce and provide a critical appraisal of the initial results of the ASPIRE HIGHER program, evaluating the potential cardio-renal protective effects of aliskiren.
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