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  • Title: Devastating ochronotic arthropathy with successful bilateral hip and knee arthroplasties.
    Author: Araki K, Sudo A, Hasegawa M, Uchida A.
    Journal: J Clin Rheumatol; 2009 Apr; 15(3):138-40. PubMed ID: 19300282.
    Abstract:
    Ochronotic arthropathy is a manifestation of long-standing alkaptonuria, a rare hereditary metabolic disorder characterized by the absence of the enzyme homogentisic acid oxidase. We describe a patient who developed rapidly progressive destructive ochronotic arthropathy in his knee and hip joints and underwent successful bilateral total knee and hip arthroplasties.
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