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Title: Molecular recognition by contact angle: proof of concept with DNA hybridization. Author: Bergese P, Oliviero G, Colombo I, Depero LE. Journal: Langmuir; 2009 Apr 21; 25(8):4271-3. PubMed ID: 19301878. Abstract: A molecular recognition reaction supported by a solid-phase assay drives a specific change in the solid-solution interfacial tension. This prompts contact angle (CA) analysis, being a straightforward route to evaluate this property, to play the unedited role of label-free probe of the reaction. The concept is proven by the successful recognition of DNA hybridization and is further supported by the agreement between the results and the underpinning thermodynamics.[Abstract] [Full Text] [Related] [New Search]