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  • Title: Reduced sterol-phospholipid recognition in curved fluid bilayers.
    Author: Mitomo H, Chen WH, Regen SL.
    Journal: Langmuir; 2009 Apr 21; 25(8):4328-30. PubMed ID: 19301879.
    Abstract:
    Nearest-neighbor recognition experiments have been carried out in fluid liposomal membranes made from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and cholesterol using exchangeable dimers derived from 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine and cholesterol. In cholesterol-rich bilayers, the association between these two exchangeable lipids was reduced as the curvature of the membrane increases; that is, when the diameter of the liposomes was below ca. 200 nm. In sharp contrast, the mixing of these exchangeable lipids was close to random in the cholesterol-poor membranes, regardless of their curvature. The biological implications of these findings are briefly discussed.
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