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  • Title: Stimulation of L-ornithine uptake and L-citrulline and urea biosynthesis by D-arginine.
    Author: Saavedra-Molina A, Piña E.
    Journal: Biochem Int; 1991 May; 24(2):349-57. PubMed ID: 1930251.
    Abstract:
    The action of D-arginine on isolated cells and mitochondria obtained from rat liver was studied. The D-amino acid at 200 microM stimulated by 40% the rate of urea biosynthesis by isolated hepatocytes. Citrulline formation was increased 60-70% in rat liver mitochondria incubated with 10 microM D-arginine. In these mitochondria, ornithine uptake was enhanced 204% with 1 microM D-arginine. Inhibition in urea and citrulline synthesis and in ornithine uptake was recorded with high concentrations of the D-amino acid. Respiratory control in liver mitochondria with glutamate-malate was inhibited 32% by 100 microM D-arginine. In isolated mitochondria loaded with Fluo-3-acetoxymethyl (AM) ester, 50 microM D-arginine diminished the matrix free calcium concentration.
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