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  • Title: Antibodies against oxidized LDL and apolipoprotein E polymorphism in demented patients.
    Author: Bednarska-Makaruk M, Rodo M, Graban A, Lojkowska W, Bochyńska A, Ryglewicz D, Wehr H.
    Journal: J Neurol Sci; 2009 Aug 15; 283(1-2):137-8. PubMed ID: 19303604.
    Abstract:
    In serum of 114 patients with dementia and of 102 controls the level of IG class immunoglobulins directed against oxidized LDL and lipids were determined. In isolated DNA apolipoprotein E gene (APOE) polymorphism was identified. In some individuals very high levels of the antibodies were observed. exceeding the 90 percentile in the investigated group. The prevalence of very high anti-ox LDL antibodies level was significantly more frequent in the carriers of epsilon2 allele and less frequent in the carriers of epsilon4 allele.
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