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  • Title: Influence of myocardial fibrosis and blood oxygenation on heart T2* values in thalassemia patients.
    Author: Meloni A, Pepe A, Positano V, Favilli B, Maggio A, Capra M, Lo Pinto C, Gerardi C, Santarelli MF, Midiri M, Landini L, Lombardi M.
    Journal: J Magn Reson Imaging; 2009 Apr; 29(4):832-7. PubMed ID: 19306406.
    Abstract:
    PURPOSE: To determine whether T2* measurements quantifying myocardial iron overload in thalassemia patients are influenced by myocardial fibrosis and blood oxygenation. MATERIALS AND METHODS: Multislice multiecho T2* was performed in 94 thalassemia patients in order to quantify myocardial iron overload. The left ventricle was automatically segmented into a 16-segment standardized heart model, and the T2* value on each segment as well as the global T2* were calculated. Delayed enhanced cardiovascular magnetic resonance (DE-CMR) images were obtained to detect myocardial fibrosis. The blood oxygenation was assessed by the noninvasive measurement of partial pressure of oxygen (pO2). RESULTS: Myocardial fibrosis was detected in 31 patients (33%). The global T2* value in patients with fibrosis was comparable with that of patients without fibrosis (P = 0.88) and T2* values in segments with fibrosis were comparable with those in segments without fibrosis (P = 0.83). The global T2* value was not correlated with the pO2 (Spearman's coefficient of correlation = 0.99). CONCLUSION: Myocardial fibrosis and blood oxygenation did not significantly affect the T2* values. These data further support the use of heart T2* as equivalent of heart iron in the clinical arena.
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