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  • Title: Measurement of DNA morphological parameters at highly entangled regime on surfaces.
    Author: Calò A, Stoliar P, Bystrenova E, Valle F, Biscarini F.
    Journal: J Phys Chem B; 2009 Apr 16; 113(15):4987-90. PubMed ID: 19309127.
    Abstract:
    The morphology of circular DNA deposited from a solution on the mica surface is analyzed from the power spectrum density (PSD) of the atomic force microscopy (AFM) images. Sample morphology is modulated in a broad range of concentration C from isolated molecules to highly entangled networks. DNA exhibits a multiaffine behavior with two correlation length scales: the persistence length P which remains constant ( approximately 50 nm) within the C range and the intermolecular distance xi which exhibits a decay with increasing C. Applying a diffusion based model in which xi scales as xi approximately D(-0.25).C(-0.5), we extracted the DNA diffusion coefficient D approximately 2 x 10(-7) cm(2)/s. This value is consistent with a high-molecular-weight plasmid DNA supercoiled in the solution.
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