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  • Title: The role of transferrin and citrate in cellular uptake of aluminium.
    Author: McGregor SJ, Brock JH, Halls D.
    Journal: Biol Met; 1991; 4(3):173-5. PubMed ID: 1931437.
    Abstract:
    The ability of human erythroleukaemia K562 cells to take up aluminium from Al-transferrin and Al-citrate has been examined. Uptake from Al-transferrin was dose-dependent over the range 68-544 ng/ml of aluminium, and increased over a 12-day period. In contrast, uptake from Al-citrate was low even at an aluminium concentration of 6800 ng/ml and did not increase over time. Neither form of aluminium greatly affected cell growth. It is concluded that Al-transferrin, rather than Al-citrate, is the physiologically relevant form of this metal with respect to cellular uptake, but that any metabolic abnormalities induced by aluminium do not affect proliferation of this cell line.
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