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  • Title: New hydrazone derivatives of adriamycin and their immunoconjugates--a correlation between acid stability and cytotoxicity.
    Author: Kaneko T, Willner D, Monkovíc I, Knipe JO, Braslawsky GR, Greenfield RS, Vyas DM.
    Journal: Bioconjug Chem; 1991; 2(3):133-41. PubMed ID: 1932212.
    Abstract:
    New N-substituted hydrazine linkers were synthesized and their hydrazone derivatives of adriamycin were prepared. These functionalized adriamycin derivatives were conjugated with a monoclonal antibody, 5E9. The release rate of adriamycin from the hydrazones and from some of the conjugates was studied, and their relationship to the IC50's of the conjugate against 5E9-positive Daudi cells was investigated.
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