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  • Title: The highly enantioselective phase-transfer catalytic mono-alkylation of malonamic esters.
    Author: Kim MH, Choi SH, Lee YJ, Lee J, Nahm K, Jeong BS, Park HG, Jew SS.
    Journal: Chem Commun (Camb); 2009 Feb 21; (7):782-4. PubMed ID: 19322440.
    Abstract:
    The phase-transfer catalytic alkylation of N,N-dialkylmalonamic tert-butyl esters in the presence of 1 mol% of (S,S)-3,4,5-trifluorophenyl-NAS bromide afforded highly enantioselective (S)-mono-alpha-alkylated products (up to 96% ee), which could be readily converted into versatile chiral building blocks without loss of chirality.
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