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  • Title: Anti-tuberculosis drug resistance and HIV co-infection in Phnom Penh, Cambodia.
    Author: Sar B, Keo C, Leng C, Saman M, Min DC, Chan S, Monchy D, Sarthou JL.
    Journal: Southeast Asian J Trop Med Public Health; 2009 Jan; 40(1):104-7. PubMed ID: 19323041.
    Abstract:
    The objective of this study was to observe the prevalence of drug resistance in Mycobacterium tuberculosis isolates in HIV associated tuberculosis co-infected patients in Phnom Penh City. The isolates of M. tuberculosis were collected during active laboratory-based surveillance. Of the 98 isolates studied, M. tuberculosis resistance to isoniazid was seen in 23.5%, resistance to rifampicin was seen in 16.3% and multidrug-resistance (MDR-TB) was seen in 5.1%. Our findings reveal an alarmingly high level of resistance to isoniazid and rifampicin, and confirms the need for drug susceptibility testing to guide treatment in patients with culture positive tuberculosis.
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