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  • Title: [Oxidative modification of cytochrome P-450 during its function. I. Comparative study of the inactivation of cytochrome P-450 LM2 in various systems].
    Author: Tret'iakova LZ, Adrianov NV, Dzhuzenova ChS, Dovgiĭ AI, Archakov AI.
    Journal: Biokhimiia; 1991 Jul; 56(7):1190-9. PubMed ID: 1932346.
    Abstract:
    The changes in the content of purified isolated cytochrome P-450 LM2 under the action of hydrogen peroxide and during its operation in a soluble reconstituted system were studied. It was found that cytochrome P-450 LM2 inactivation by hydrogen peroxide is accompanied by a decrease in the hemoprotein activity, loss of heme, oxidation of SH-groups and changes in the oligomeric state of the enzyme. There were some differences in the mechanisms of cytochrome P-450 LM2 inactivation under the action of H2O2 and during catalysis.
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