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  • Title: Glucose-sensitive microcapsules from glutaraldehyde cross-linked hemoglobin and glucose oxidase.
    Author: Qi W, Yan X, Duan L, Cui Y, Yang Y, Li J.
    Journal: Biomacromolecules; 2009 May 11; 10(5):1212-6. PubMed ID: 19323511.
    Abstract:
    We have fabricated the glucose-sensitive protein hollow microcapsules from hemoglobin (Hb) and glucose oxidase (GOx) via layer-by-layer technique with glutaraldehyde (GA) as a cross-linking agent. We demonstrated the coupled enzymatic reactions between Hb and GOx within capsules by means of CLSM. The real-time monitoring of the consumption of glucose may be useful for the design of a glucose sensor. Furthermore, to further study the effect of glucose on the capsules, we investigated the wall permeability of (Hb/GOx)(5) capsules. It was found that the glucose consumption could enhance the permeability of (Hb/GOx)(5) capsules. This is significant for the development of advanced drug delivery devices. Therefore, the fabricated Hb/GOx capsules may be a potential candidate for the creation of multifunctional devices.
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