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  • Title: Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis.
    Author: Mazure CM, Nelson JC, Jatlow PI, Bowers MB.
    Journal: Biol Psychiatry; 1991 Sep 01; 30(5):475-82. PubMed ID: 1932395.
    Abstract:
    The relationship of plasma free homovanillic acid (HVA) and methoxyhydroxyphenylglycol (MHPG) to early clinical response was prospectively studied in a new series of acutely psychotic inpatients given a fixed dose of perphenazine elixir for 10 days. Elevated pretreatment plasma HVA but not MHPG was significantly associated with good response. Change in HVA was correlated with a favorable response and a significant decline in MHPG was found in responders. Results suggest that HVA can provide a useful clinical predictor of response, and that both dopamine metabolism and noradrenergic functioning, as measured by plasma HVA and MHPG, are reduced in effective neuroleptic treatment.
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