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  • Title: Discovery of the butenyl-spinosyn insecticides: novel macrolides from the new bacterial strain Saccharopolyspora pogona.
    Author: Lewer P, Hahn DR, Karr LL, Duebelbeis DO, Gilbert JR, Crouse GD, Worden T, Sparks TC, Edwards PM, Graupner PR.
    Journal: Bioorg Med Chem; 2009 Jun 15; 17(12):4185-96. PubMed ID: 19324553.
    Abstract:
    A new bacterium, Saccharopolyspora pogona (NRRL30141) was discovered which produced a series of very potent insecticidal compounds structurally related to the 'classical' (i.e., C-21-ethyl) spinosyns. A series of fermentations gave sufficient extract to allow the isolation and characterization of a total of 31 new metabolites. The majority of these compounds contained a but-1-enyl group at C-21 of the macrolide in place of the ethyl group in the 'classical' spinosyn series, corresponding to an additional acetate group incorporated during their biosynthesis. Additionally a variety of other new functionality was seen including hydroxylations, several novel forosamine sugar replacements, and a novel 14-membered macrolide ring analog.
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