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  • Title: Construction of carbo- and heterocycles using radical relay cyclizations initiated by alkoxy radicals.
    Author: Zhu H, Wickenden JG, Campbell NE, Leung JC, Johnson KM, Sammis GM.
    Journal: Org Lett; 2009 May 07; 11(9):2019-22. PubMed ID: 19326922.
    Abstract:
    An efficient method for the rapid construction of carbo- and heterocycles has been developed using radical relay cyclizations initiated by alkoxy radicals. Linear substrates were cyclized to form a wide range of cyclopentane, pyrrolidine, tetrahydropyran, and tetrahydrofuran derivatives in excellent yields. This methodology was utilized as a key step in the synthesis of the tetrahydrofuran fragment in (-)-amphidinolide K.
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