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  • Title: Prodigiosin biosynthesis gene cluster in the roseophilin producer Streptomyces griseoviridis.
    Author: Kawasaki T, Sakurai F, Nagatsuka SY, Hayakawa Y.
    Journal: J Antibiot (Tokyo); 2009 May; 62(5):271-6. PubMed ID: 19329986.
    Abstract:
    Streptomyces griseoviridis 2464-S5 produces prodigiosin R1, a tripyrrole antibiotic, and roseophilin, a structurally related compound containing two pyrrole and one furan rings. A gene cluster for the biosynthesis of a prodigiosin was identified in S. griseoviridis. The cluster consisted of 24 open reading frames, including 21 genes (rphD-rphZ) homologous to prodigiosin biosynthesis genes in the red cluster in Streptomyces coelicolor A3(2). The expression of rphN in S. coelicolor lacking redN restored the production of prodigiosin.
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