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  • Title: GABAergic-serotonergic interactions in regulating lordosis.
    Author: Luine V, Cowell J, Frankfurt M.
    Journal: Brain Res; 1991 Aug 09; 556(1):171-4. PubMed ID: 1933350.
    Abstract:
    The GABAB agonist, baclofen, causes a dose-dependent decrease in lordosis, and this effect is attenuated following hypothalamic serotonin, (5-HT) lesions. Baclofen administration is associated with decreased 5-HT activity in the medial preoptic (mPOA) and ventromedial nuclei and enhanced 5-HT activity in the midbrain central gray, and with enhanced norepinephrine activity in the mPOA. Interactions between gamma-aminobutyric acid (GABA) and 5-HT may, therefore, be important for the activation of lordosis.
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