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  • Title: [Afobazole influence on antinociceptive properties of morphine].
    Author: Kolik LG, Zhukov VN, Seredenin SB.
    Journal: Eksp Klin Farmakol; 2009; 72(1):22-3. PubMed ID: 19334506.
    Abstract:
    The effects of afobazole (1.0 and 10.0 mg/kg, i.p.) on the antinociceptive properties of morphine (3.0 mg/kg, i.p.) were studied in mice. It is shown that afobazole attenuates the analgesic action of morphine in the "hot plate" and "tail flick" tests. This effect was prevented by sigma 1 receptor antagonist haloperidol (2.0 mg/kg, i.p.). Data obtained suggested that a decrease in the morphine antinociceptive action by afobazole is related to its agonistic interaction with sigma 1 receptors at supraspinal and spinal levels.
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