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  • Title: [Expression, characterization of recombinant human soluble BAFF secreted from CHO cell].
    Author: Wu HT, Yan XM, Hu YL, Diao ZY, Wu J, Zhang SQ.
    Journal: Mol Biol (Mosk); 2009; 43(1):85-90. PubMed ID: 19334529.
    Abstract:
    B cell-activating factor of the TNF family (BAFF) is critical for B cell maturation and survival. Here, we constructed a stable CHO cell line, in which the expression level of soluble form of BAFF (sBAFF) was raised from 0.13 microg/ml to 0.55 microg/ml. Purified recombinant sBAFF from these CHO cells not only bound to its receptors but also co-stimulated the proliferation of human peripheral blood B lymphocyte in vitro. These results provided us with a useful basis for further studies about sBAFF-related research.
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